The subversion of toll-like receptor signaling by bacterial and viral proteases during the development of infectious diseases. Ciaston I, Dobosz E, Potempa J, Koziel J. Mol Aspects Med. 2022 Sep 21;88:101143.
Carbamylation of Integrin α IIb β 3: The Mechanistic Link to Platelet Dysfunction in ESKD. Binder V, Chruścicka-Smaga B, Bergum B, Jaisson S, Gillery P, Sivertsen J, Hervig T, Kaminska M, Tilvawala R, Nemmara VV, Thompson PR, Potempa J, Marti HP, Mydel P. J Am Soc Nephrol. 2022 Aug 29;33(10):1841-56.
A unique bacterial secretion machinery with multiple secretion centers. Song L, Perpich JD, Wu C, Doan T, Nowakowska Z, Potempa J, Christie PJ, Cascales E, Lamont RJ, Hu B. Proc Natl Acad Sci U S A. 2022 May 3;119(18):e2119907119.
Proteolytic Activity-Independent Activation of the Immune Response by Gingipains from Porphyromonas gingivalis. Ciaston I, Budziaszek J, Satala D, Potempa B, Fuchs A, Rapala-Kozik M, Mizgalska D, Dobosz E, Lamont RJ, Potempa J, Koziel J. mBio. 2022 Jun 28;13(3):e0378721.
TLR2 Activation by Porphyromonas gingivalis Requires Both PPAD Activity and Fimbriae. Wielento A, Bereta GP, Łagosz-Ćwik KB, Eick S, Lamont RJ, Grabiec AM, Potempa J. Front Immunol. 2022 Apr 1;13:823685.
May Staphylococcuslugdunensis Be an Etiological Factor of Chronic Maxillary Sinuses Infection? Kosecka-Strojek M, Wolska-Gębarzewska M, Podbielska-Kubera A, Samet A, Krawczyk B, Międzobrodzki J, Michalik M. Int J Mol Sci. 2022 Jun 9;23(12):6450.
Uncovering the Oral Dysbiotic Microbiota as Masters of Neutrophil Responses in the Pathobiology of Periodontitis. Prucsi Z, Płonczyńska A, Potempa J, Sochalska M. Front Microbiol. 2021 Oct 11;12:729717.
Intermolecular latency regulates the essential C-terminal signal peptidase and sortase of the Porphyromonas gingivalis type-IX secretion system. Mizgalska D, Goulas T, Rodríguez-Banqueri A, Veillard F, Madej M, Małecka E, Szczesniak K, Ksiazek M, Widziołek M, Guevara T, Eckhard U, Solà M, Potempa J, Gomis-Rüth FX. Proc Natl Acad Sci U S A. 2021 Oct 5;118(40):e2103573118.
Latency, thermal stability, and identification of an inhibitory compound of mirolysin, a secretory protease of the human periodontopathogen Tannerella forsythia. Zak KM, Bostock MJ, Waligorska I, Thøgersen IB, Enghild JJ, Popowicz GM, Grudnik P, Potempa J, Ksiazek M. J Enzyme Inhib Med Chem. 2021 Dec;36(1):1267-1281.
Subversion of Lipopolysaccharide Signaling in Gingival Keratinocytes via MCPIP-1 Degradation as a Novel Pathogenic Strategy of Inflammophilic Pathobionts. Gasiorek A, Dobosz E, Potempa B, Ciaston I, Wilamowski M, Oruba Z, Lamont RJ, Jura J, Potempa J, Koziel J. mBio. 2021 Jun 29;12(3):e0050221.
hTERT-immortalized gingival fibroblasts respond to cytokines but fail to mimic primary cell responses to Porphyromonas gingivalis. Lagosz-Cwik KB, Wielento A, Lipska W, Kantorowicz M, Darczuk D, Kaczmarzyk T, Gibbs S, Potempa J, Grabiec AM. Sci Rep. 2021 May 24;11(1):10770.
Murine myeloid cell MCPIP1 suppresses autoimmunity by regulating B-cell expansion and differentiation. Dobosz E, Lorenz G, Ribeiro A, Würf V, Wadowska M, Kotlinowski J, Schmaderer C, Potempa J, Fu M, Koziel J, Lech M. Dis Model Mech. 2021 Mar 18;14(3):dmm047589.
MCPIP-1 Restricts Inflammation via Promoting Apoptosis of Neutrophils. Dobosz E, Wadowska M, Kaminska M, Wilamowski M, Honarpisheh M, Bryzek D, Potempa J, Jura J, Lech M, Koziel J. Front Immunol. 2021 Feb 26;12:627922.
PorZ, an Essential Component of the Type IX Secretion System of Porphyromonas gingivalis, Delivers Anionic Lipopolysaccharide to the PorU Sortase for Transpeptidase Processing of T9SS Cargo Proteins. Madej M, Nowakowska Z, Ksiazek M, Lasica AM, Mizgalska D, Nowak M, Jacula A, Bzowska M, Scavenius C, Enghild JJ, Aduse-Opoku J, Curtis MA, Gomis-Rüth FX, Potempa J. mBio. 2021 Feb 23;12(1):e02262-20.
Distribution and antibiotic-resistance of different Staphylococcus species identified by matrix assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) isolated from the oral cavity. Garbacz K, Wierzbowska M, Kwapisz E, Kosecka-Strojek M, Bronk M, Saki M, Międzobrodzki J. J Oral Microbiol. 2021 Sep 26;13(1):1983322.
Citrullination-Resistant LL-37 Is a Potent Antimicrobial Agent in the Inflammatory Environment High in Arginine Deiminase Activity. Bryzek D, Golda A, Budziaszek J, Kowalczyk D, Wong A, Bielecka E, Shakamuri P, Svoboda P, Pohl J, Potempa J, Koziel J. Int J Mol Sci. 2020 Nov 30;21(23):9126.
Structural and functional insights into oligopeptide acquisition by the RagAB transporter from Porphyromonas gingivalis. Madej M, White JBR, Nowakowska Z, Rawson S, Scavenius C, Enghild JJ, Bereta GP, Pothula K, Kleinekathoefer U, Baslé A, Ranson NA, Potempa J, van den Berg B. Nat Microbiol. 2020 Aug;5(8):1016-1025.
Plasmin inhibition by bacterial serpin: Implications in gum disease. Sochaj-Gregorczyk A, Ksiazek M, Waligorska I, Straczek A, Benedyk M, Mizgalska D, Thøgersen IB, Enghild JJ, Potempa J. FASEB J. 2020 Jan;34(1):619-630.
HDAC3 Regulates Gingival Fibroblast Inflammatory Responses in Periodontitis. Lagosz KB, Bysiek A, Macina JM, Bereta GP, Kantorowicz M, Lipska W, Sochalska M, Gawron K, Kaczmarzyk T, Chomyszyn-Gajewska M, Fossati G, Potempa J, Grabiec AM. J Dent Res. 2020 Jan;99(1):98-106.
Presence of egc-positive major clones ST 45, 30 and 22 among methicillin-resistant and methicillin-susceptible oral Staphylococcus aureus strains. Kwapisz E, Garbacz K, Kosecka-Strojek M, Schubert J, Bania J, Międzobrodzki J. Sci Rep. 2020 Nov 3;10(1):18889.
Proteolytic processing and activation of gingipain zymogens secreted by T9SS of Porphyromonas gingivalis. Veillard F, Sztukowska M, Nowakowska Z, Mizgalska D, Thøgersen IB, Enghild JJ, Bogyo M, Potempa B, Nguyen KA, Potempa J. Biochimie. 2019 Jun 15.
The Bactericidal Activity of Temporin Analogues Against Methicillin Resistant Staphylococcus aureus. Golda A, Kosikowska-Adamus P, Kret A, Babyak O, Wójcik K, Dobosz E, Potempa J, Lesner A, Koziel J. Int J Mol Sci. 2019 Sep 25;20(19).
Discovery of Novel Potential Reversible Peptidyl Arginine Deiminase Inhibitor. Aliko A, Kamińska M, Falkowski K, Bielecka E, Benedyk-Machaczka M, Malicki S, Kozieł J, Wong A, Bryzek D, Kantyka T, Mydel P. Int J Mol Sci. 2019 May 2;20(9).
Triggering NETosis via protease-activated receptor (PAR)-2 signaling as a mechanism of hijacking neutrophils function for pathogen benefits. Bryzek D, Ciaston I, Dobosz E, Gasiorek A, Makarska A, Sarna M, Eick S, Puklo M, Lech M, Potempa B, Potempa J, Koziel J. PLoS Pathog. 2019 May 20;15(5):e1007773.
BET Bromodomain Inhibitors Suppress Inflammatory Activation of Gingival Fibroblasts and Epithelial Cells From Periodontitis Patients. Maksylewicz A, Bysiek A, Lagosz KB, Macina JM, Kantorowicz M, Bereta G, Sochalska M, Gawron K, Chomyszyn-Gajewska M, Potempa J, Grabiec AM. Front Immunol. 2019 Apr 30;10:933.
Porphyromonas gingivalis in Alzheimer's disease brains: Evidence for disease causation and treatment with small-molecule inhibitors. Dominy SS, Lynch C, Ermini F, Benedyk M, Marczyk A, Konradi A, Nguyen M, Haditsch U, Raha D, Griffin C, Holsinger LJ, Arastu-Kapur S, Kaba S, Lee A, Ryder MI, Potempa B, Mydel P, Hellvard A, Adamowicz K, Hasturk H, Walker GD, Reynolds EC, Faull RLM, Curtis MA, Dragunow M, Potempa J. Sci Adv. 2019 Jan 23;5(1):eaau3333.
Development and Validation of a Reference Data Set for Assigning Staphylococcus Species Based on Next Generation Sequencing of 16S-23S rRNA Region. Kosecka-Strojek M, Sabat AJ, Akkerboom V, Becker K, van Zanten E, Wisselink G, Miedzobrodzki J, Kooistra-Smid M, Friedrich AW. Front Cell Infect Microbiol. 2019 Aug 7;9:278.
Development of a Reference Data Set for Assigning Streptococcus and Enterococcus Species Based on Next Generation Sequencing of 16S-23S rRNA Region. Kosecka-Strojek M, Sabat AJ, Akkerboom V, Kooistra-Smid M, Miedzobrodzki J, Friedrich AW. Antimicrob Resist Infect Control. 2019 Nov 15;8:178. doi: 10.1186/s13756-019-0622-3
The impact of Porphyromonas gingivalis peptidylarginine deiminase on biofilm formation, invasion and transcriptional landscape of epithelial cells. Aliko A, Kamińska M, Bergum B, Gawron K, Benedyk M, Hellvard A, Jonsson R, Lamont RJ, Malicki S, Potempa J, Delaleu N, Mydel P. Sci Rep. 2018 Sep 20;8(1):14144. doi: 10.1038/s41598-018-32603-y.
A Novel Biological Role for Peptidyl-Arginine Deiminases: Citrullination of Cathelicidin LL-37 Controls the Immunostimulatory Potential of Cell-Free DNA. Wong A, Bryzek D, Dobosz E, Scavenius C, Svoboda P, Rapala-Kozik M, Lesner A, Frydrych I, Enghild J, Mydel P, Pohl J, Thompson PR, Potempa J, Koziel J. J Immunol. 2018 Apr 1;200(7):2327-2340.
The Bacteroidetes Q-Rule: Pyroglutamate in Signal Peptidase I Substrates. Bochtler M, Mizgalska D, Veillard F, Nowak ML, Houston J, Veith P, Reynolds EC, Potempa J. Front Microbiol. 2018 Mar 1;9:230.
The case for periodontitis in the pathogenesis of rheumatoid arthritis. Potempa J, Mydel P, Koziel J. Nat Rev Rheumatol. 2017 Oct;13(10):606-620. doi: 10.1038/nrrheum.2017.132. Epub 2017 Aug 24. Review.
Inactive Gingipains from P. gingivalis Selectively Skews T Cells toward a Th17 Phenotype in an IL-6 Dependent Manner. Glowczyk I, Wong A, Potempa B, Babyak O, Lech M, Lamont RJ, Potempa J, Koziel J. Front Cell Infect Microbiol. 2017 Apr 27;7:140. doi: 10.3389/fcimb.2017.00140.
The outer-membrane export signal of Porphyromonas gingivalis type IX secretion system (T9SS) is a conserved C-terminal β-sandwich domain. de Diego I, Ksiazek M, Mizgalska D, Koneru L, Golik P, Szmigielski B, Nowak M, Nowakowska Z, Potempa B, Houston JA, Enghild JJ, Thøgersen IB, Gao J, Kwan AH, Trewhella J, Dubin G, Gomis-Rüth FX, Nguyen KA, Potempa J. Sci Rep. 2016;6:23123.
MCPIP-1, Alias Regnase-1, Controls Epithelial Inflammation by Posttranscriptional Regulation of IL-8 Production. Dobosz E, Wilamowski M, Lech M, Bugara B, Jura J, Potempa J, Koziel J. J Innate Immun. 2016;8(6):564-578.
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Unique network of attack, defence and competence factors on the bacterial outer membrane of periodontopathogenic Tannerella forsythia. Książek, M., Goulas, T., Mizgalska, D., Rodríguez-Banqueri, A., Eckhard, U., Veillard, F., Waligórska, I., Benedyk-Machaczka, M., Sochaj-Gregorczyk, A., Madej, M., Thøgersen, I.B., Enghild, J.J., Cuppari, A., Arolas, J.L., de Diego, I., López-Pelegrín. M., Garcia-Ferrer, I., Guevara, T., Dive, V., Zani, M.-L., Moreau, T., Potempa, J. & Gomis-Rüth, F.X. Chem. Sci. 14: 869-888.
Mapping of DNA methylation-sensitive cellular processes in gingival and periodontal ligament fibroblasts in the context of periodontal tissue homeostasis. Łagosz-Cwik, K.B., Melnykova, M., Nieboga, E., Schuster, A., Bysiek, A., Dudek, S., Lipska, W., Kantorowicz, M., Tyrakowski, M., Darczuk, D., Kaczmarzyk, T., Gilijamse, M., de Vries, T.J., Potempa, J., & Grabiec, A.M. Front Immunol. 14: 1078031.
Identification of Mycobacterium tuberculosis in pulmonary and extrapulmonary specimens of Iranian hospitalized patients during 2017-2021. Salehi, Mohammadreza; Shahsiah Reza; Khorasani, Kiarash, Mohammad; Hasannezhad, Malihe; Rahimi, Arian; Yousefi, Bahare; Aliramezani, AmirYousefi. International Journal of Mycobacteriology 12(1):p 23-27, Jan-Mar 2023
Localization and pathogenic role of the cysteine protease dentipain in Treponema denticola. Miyai-Murai Y, Okamoto-Shibayama K, Sato T, Kikuchi Y, Kokubu E, Potempa J, Ishihara K. Mol. Oral Microbiol. 38: 212-223.
The role of gingival fibroblasts in the pathogenesis of periodontitis. Wielento, A., Lagosz-Cwik, K.B., Potempa, J., & Grabiec, A.M. J. Dent. Res. 102: 489-496.
Domain shuffling of a highly mutable adhesive module drives novel adhesin generation across the bacterial kingdom. Barringer, R., Parnell, A.E., Lafita, A., Monzon, V., Back, C.R., Madej, M., Potempa, J., Nobbs, A.H., Burston, S.G., Bateman, A., & Race, P.R. Proteins 91: 1007-1020.
Phage display selection of human single domain antibodies towards karilysin, a metalloproteinase and secreted virulence factor from Tannerella forsythia. Skottrup, P.D., Ksiazek, M., & Potempa, J. J. Immunol. Meth. 516: 113458.
Bestatin as a treatment modality in experimental periodontitis. Kaminska M, Benedyk-Machaczka M, Adamowicz K, Aliko A, Drzazga K, Słysz K, Bielecka E, Potempa J, Mydel P. J. Periodontol. 94: 1338–1350.
Highly multiplexed bioactivity screening reveals human and microbiota metabolome-GPCRome interactions. Chen, H., Rosen, C., Gonzalez-Hernandez, J., Potempa, J. Ring, A., Palm, N. Cell 186: 3095-3110.e19.
Citrullination of C1-inhibitor as a mechanism of impaired complement regulation in rheumatoid arthritis. Martin, M., Nilsson, S.C., Eikrem, D., Fromell, K., Scavenius, C., Vogt, L.M., Bielecka, E., Potempa, J., Enghild, J.J., Nilsson, B., Ekdahl, K.N., Kapetanovic, M.C., & Blom, A.M. Front. Immunol. 14: 1203506.
Identification and characterization of aptameric inhibitors of human neutrophil elastase. Malicki, S., Książek, M., Sochaj-Gregorczyk, A., Kamińska, M., Golda, A., Chruścicka, B., Mizgalska, D., Potempa, J., Marti, H.P., Kozieł, J., Wieczorek, M., Pieczykolan, J., Mydel, P., & Dubin, G. J. Biol. Chem. 299: 104889.
Accessory fimbrial subunits and PPAD are necessary for TLR2 activation by Porphyromonas gingivalis. Wielento, A., Bereta, G.P., Szczęśniak, K., Jacuła, A., Terekhova, M., Artyomov, M.N., Hasegawa, Y., Grabiec, A.M. & Potempa, J. Mol. Oral Microbiol. 38: 334-346.
Antibodies against Porphyromonas gingivalis in serum and saliva and their association with periodontitis. Data from two rheumatoid arthritis cohorts in Sweden. Svärd, A., Kastbom, A., Ljungberg, K.R., Potempa, B., Potempa, J., Persson, G.R., Renvert, S., Berglund, J.S., & Söderlin, M.K. Front. Immunol. 14: 1183194.
Porphyromonas gingivalis peptidyl arginine deiminase (PPAD) in the context of the feed-forward loop of inflammation in periodontitis. Prucsi, Z., Zimny, A., Plomczynska, A., Zubrzycka, N., Potempa, J., & Sochalska, M. Int. J. Mol. Sci. 24: 12922.
A protease-responsive PEG-peptide and reversible assembly of silver clusters for the detection of Porphyromonas gingivalis enzymatic activity. Retout, M., Amer, L., Yim, W., Creyer, M.N., Lam, B., Trujillo, D.F., Potempa, J., O’Donoghue, A.J., & Jokerst, J.V. ACS Nano 17: 17308-17319.
The Bacteroidetes Q-rule and glutaminyl cyclase activity increase the stability of extracytoplasmic proteins. Szczesniak, K., Veillard, F., Scavenius, C., Chudzik, K., Ferenc, K., Bochtler, M., Potempa, J., and Mizgalska, D. mBio 14: e0098023.
Mapping of substrate binding subsite specificity of a Porphyromonas gingivalis Tpr peptidase. Staniec, D., Rut, W., Drąg, M., Burmistrz, M., Kitching, M., Potempa, J. Acta Biochim. Pol. 70: 963-968.
Poly(ethylene glycol) block-poly(sodium 4-styrenesulfonate) Copolymers as Efficient Zika Virus Inhibitors: In Vitro Studies. Botwina P, Obłoza M, Bonarek P, Szczubiałka K, Pyrć K, Nowakowska M. ACS Omega. 2023 Feb 9;8(7):6875-6883.
Studies of Streptococcus anginosus Virulence in Dictyostelium discoideum and Galleria mellonella Models. Budziaszek J, Pilarczyk-Zurek M, Dobosz E, Kozinska A, Nowicki D, Obszanska K, Szalewska-Pałasz A, Kern-Zdanowicz I, Sitkiewicz I, Koziel J. Infect Immun. 2023 May 16;91(5):e0001623.
Reversible rearrangement of the cellular cytoskeleton: A key to the broad-spectrum antiviral activity of novel amphiphilic polymers. Dabrowska A, Botwina P, Barreto-Duran E, Kubisiak A, Obloza M, Synowiec A, Szczepanski A, Targosz-Korecka M, Szczubialka K, Nowakowska M, Pyrc K. Mater Today Bio. 2023 Aug 7;22:100763.
Investigation of osteoclast cathepsin K activity in osteoclastogenesis and bone loss using a set of chemical reagents. Janiszewski T, Kołt S, Ciastoń I, Vizovisek M, Poręba M, Turk B, Drąg M, Kozieł J, Kasperkiewicz P. Cell Chem Biol. 2023 Feb 16;30(2):159-174.e8.
Discovery of Inhibitory Fragments That Selectively Target Spire2-FMN2 Interaction. Kitel R, Surmiak E, Borggräfe J, Kalinowska-Tluscik J, Golik P, Czub M, Uzar W, Musielak B, Madej M, Popowicz GM, Dubin G, Holak TA. J Med Chem. 2023 Dec 14;66(23):15715-15727.
A protocol for visualizing active cathepsin K in osteoclasts with a quenched-fluorescence-activity-based probe. Korba A, Ciastoń I, Kozieł J, Kasperkiewicz P. STAR Protoc. 2023 Jul 22;4(3):102465.
Uremic Toxin Indoxyl Sulfate Promotes Macrophage-Associated Low-Grade Inflammation and Epithelial Cell Senescence. Ribeiro A, Liu F, Srebrzynski M, Rother S, Adamowicz K, Wadowska M, Steiger S, Anders HJ, Schmaderer C, Koziel J, Lech M. Int J Mol Sci. 2023 Apr 28;24(9):8031.
Feline herpesvirus 1 (FHV-1) enters the cell by receptor-mediated endocytosis. Synowiec A, Dąbrowska A, Pachota M, Baouche M, Owczarek K, Niżański W, Pyrc K. J Virol. 2023 Aug 31;97(8):e0068123.
Depletion of Mcpip1 in murine myeloid cells results in intestinal dysbiosis followed by allergic inflammation. Szukala W, Pilarczyk-Zurek M, Folkert J, Kotlinowski J, Koziel J, Jura J. Biochim Biophys Acta Mol Basis Dis. 2023 May 29;1869(7):166764.
Current types of staphylococcal cassette chromosome mec (SCCmec) in clinically relevant coagulase-negative staphylococcal (CoNS) species. Wolska-Gębarzewska M, Międzobrodzki J, Kosecka-Strojek M. Crit Rev Microbiol. 2023 Oct 26:1-17.
Clinical and microbiological patterns in critically ill patients with catheter-associated UTI: a report from Iran. Salehi Mohammadreza, Robati Dariush, SevedAlinaghi SevedAhmad, Seifi Arash, Aliramezani Amir, Dehghan Manshadi Seyed Ali, Afarinesh Khaki Pegah, Zamani Fariba. Journal of Infection in Developing Countries 2023 vol. 17, no.1 p. 129-134
Towards controlling the local bone tissue remodeling: multifunctional injectable composites for osteoporosis treatment. Klara Joanna, Onal Sylwia, Kowalczyk Andrzej, Horak Wojciech, Wójcik Kinga, Lewandowska-Łańcucka Joanna. International Journal of Molecular Sciences 2023 vol. 24 no. 5
Determine phenotypical patterns of resistance to antibiotics in COVID-19 patients with associated bacterial infection : largest medical center in Iran. Mohammadnejad Esmaeil, Seifi Arash, Gheshlagh Reza Ghanei, Aliramezani Amir, Ghazi Samrand Fattah, Salehi Mohammadreza, Manshadi Seyed Ali Dehghan, Orandi Amirhossein. Iranian Journal of Microbiology. - 2023 vol. 15 no. 3 p. 336-342.
An evaluation of the usability of argon plasma-treated bacterial cellulose as a carrier for controlled releases of glycoside hydrolases PelAℎ and PslGℎ, which are able to eradicate biofilm. Charęza Magdalena, Ekiert Ewa, Moszyński Dariusz, Madej Mariusz, Jędrzejczak-Silicka Magdalena, Drozd Radosław. Applied Sciences. - 2023 vol. 13 no. 13
MCPIP1 controls effects of myeloid cells on skin carcinogenesis and hair growth. Szukała Weronika, Rumienczyk Izabela, Mikula Michal, Goryca Krzysztof, Eckhart Leopold, Kozieł Joanna, Jura Jolanta, Lichawska-Cieślar Agata. Journal of Investigative Dermatology. - 2023. - ISSN 0022-202X. - eISSN 1523-1747
The Multi-Component causes of late neonatal sepsis-can we regulate them? Pilarczyk-Zurek M, Majka G, Skowron B, Baranowska A, Piwowar M, Strus M. Nutrients. 2022 Jan 7;14(2):243.
Pleckstrin levels are increased in patients with chronic periodontitis and regulated via the MAP kinase-p38α signaling pathway in gingival fibroblasts. Alim MA, Njenda D, Lundmark A, Kaminska M, Jansson L, Eriksson K, Kats A, Johannsen G, Arvidsson CK, Mydel PM, Yucel-Lindberg T. Front Immunol. 2022 Jan 11;12:801096.
Diabetes medication metformin inhibits osteoclast formation and activity in in vitro models for periodontitis. Tao LY, Łagosz-Ćwik KB, Hogervorst JMA, Schoenmaker T, Grabiec AM, Forouzanfar T, van der Weijden FA, de Vries TJ. Front Cell Dev Biol. 2022 Jan 13;9:777450.
Macrophage-specific MCPIP1/Regnase-1 attenuates kidney ischemia-reperfusion injury by shaping the local inflammatory response and tissue regeneration. Ribeiro A, Dobosz E, Krill M, Köhler P, Wadowska M, Steiger S, Schmaderer C, Koziel J, Lech M. Cells. 2022 Jan 24;11(3):397.
Shut-Down of Type IX Protein Secretion Alters the Host Immune Response to Tannerella forsythia and Porphyromonas gingivalis. Braun ML, Tomek MB, Grünwald-Gruber C, Nguyen PQ, Bloch S, Potempa JS, Andrukhov O, Schäffer C. Front Cell Infect Microbiol. 2022 Feb 10;12:835509.
Antibodies to Porphyromonas gingivalis Are Increased in Patients with Severe Periodontitis, and Associate with Presence of Specific Autoantibodies and Myocardial Infarction. de Vries C, Ruacho G, Kindstedt E, Potempa BA, Potempa J, Klinge B, Lundberg P, Svenungsson E, Lundberg K.J Clin Med. 2022 Feb 15;11(4):1008.
TLR2 Activation by Porphyromonas gingivalis Requires Both PPAD Activity and Fimbriae. Wielento A, Bereta GP, Łagosz-Ćwik KB, Eick S, Lamont RJ, Grabiec AM, Potempa J. Front Immunol. 2022 Apr 1;13:823685.
Immune-instructive copolymer scaffolds using plant-derived nanoparticles to promote bone regeneration. Suliman S, Mieszkowska A, Folkert J, Rana N, Mohamed-Ahmed S, Fuoco T, Finne-Wistrand A, Dirscherl K, Jørgensen B, Mustafa K, Gurzawska-Comis K. Inflamm Regen. 2022 Apr 3;42(1):12.
Proteolytic Activity-Independent Activation of the Immune Response by Gingipains from Porphyromonas gingivalis. Ciaston I, Budziaszek J, Satala D, Potempa B, Fuchs A, Rapala-Kozik M, Mizgalska D, Dobosz E, Lamont RJ, Potempa J, Koziel J. mBio. 2022 May 2:e0378721.
A unique bacterial secretion machinery with multiple secretion centers. Song L, Perpich JD, Wu C, Doan T, Nowakowska Z, Potempa J, Christie PJ, Cascales E, Lamont RJ, Hu B. Proc Natl Acad Sci U S A. 2022 May 3;119(18):e2119907119.
Imaging of Clear Cell Renal Carcinoma with Immune Checkpoint Targeting Aptamer-Based Probe. Malicki S, Pucelik B, Żyła E, Benedyk-Machaczka M, Gałan W, Golda A, Sochaj-Gregorczyk A, Kamińska M, Encarnação JC, Chruścicka B, Marti HP, Chen TJ, Magiera-Mularz K, Zięba B, Holak TA, Dąbrowski JM, Czarna A, Kozieł J, Mydel P, Dubin G. Pharmaceuticals (Basel). 2022 Jun 1;15(6):697.
May Staphylococcus lugdunensis Be an Etiological Factor of Chronic Maxillary Sinuses Infection? Kosecka-Strojek M, Wolska-Gębarzewska M, Podbielska-Kubera A, Samet A, Krawczyk B, Międzobrodzki J, Michalik M. Int J Mol Sci. 2022 Jun 9;23(12):6450.
Proteolytic Activity-Independent Activation of the Immune Response by Gingipains from Porphyromonas gingivalis. Ciaston I, Budziaszek J, Satala D, Potempa B, Fuchs A, Rapala-Kozik M, Mizgalska D, Dobosz E, Lamont RJ, Potempa J, Koziel J. mBio. 2022 Jun 28;13(3):e0378721.
Pros and cons of causative association between periodontitis and rheumatoid arthritis. Koziel J, Potempa J. Periodontol 2000. 2022 Jun;89(1):8398.
The Clinical View on Streptococcus anginosus Group - Opportunistic Pathogens Coming Out of Hiding. Pilarczyk-Zurek M, Sitkiewicz I, Koziel J. Front Microbiol. 2022 Jul 8;13:956677.
Host and bacterial factors linking periodontitis and rheumatoid arthritis. Krutyhołowa A, Strzelec K, Dziedzic A, Bereta GP, Łazarz-Bartyzel K, Potempa J, Gawron K. Front Immunol. 2022 Aug 25;13: 980805.
Porphyromonas gingivalis Gingipains-Mediated Degradation of Plasminogen Activator Inhibitor-1 Leads to Delayed Wound Healing Responses in Human Endothelial Cells. Song LT, Tada H, Nishioka T, Nemoto E, Imamura T, Potempa J, Li CY, Matsushita K, Sugawara S. J Innate Immun. 2022;14(4):306-319.
The subversion of toll-like receptor signaling by bacterial and viral proteases during the development of infectious diseases. Ciaston I, Dobosz E, Potempa J, Koziel J. Mol Aspects Med. 2022 Sep 21;88:101143.
MCP-induced Protein 1 Participates in Macrophage-Dependent Endotoxin Tolerance. Wadowska M, Dobosz E, Golda A, Bryzek D, Lech M, Fu M, Koziel J. J Immunol. 2022 Oct 1;209(7):1348-1358.
Carbamylation of Integrin α IIb β 3: The Mechanistic Link to Platelet Dysfunction in ESKD. Binder V, Chruścicka-Smaga B, Bergum B, Jaisson S, Gillery P, Sivertsen J, Hervig T, Kaminska M, Tilvawala R, Nemmara VV, Thompson PR, Potempa J, Marti HP, Mydel P. J Am Soc Nephrol. 2022 Oct 33(10):1841-56.
Response regulator PorX coordinates oligonucleotide signalling and gene expression to control the secretion of virulence factors. Schmitz C, Madej M, Nowakowska Z, Cuppari A, Jacula A, Ksiazek M, Mikruta K, Wisniewski J, Pudelko-Malik N, Saran A, Zeytuni N, Mlynarz P, Lamont RJ, Usón I, Siksnys V, Potempa J, Solà M. Nucleic Acids Res. 2022 Nov 28;50(21): 12558-12577.
Purification and in vitro evaluation of an anti-HER2 affibody-monomethyl auristatin E conjugate in HER2-positive cancer cells. Damiani Isabella, Castiglioni Silvia, Sochaj-Gregorczyk Alicja, Bonacina Fabrizia, Colombo Irma, Rusconi Valentina, Otlewski Jacek, Corsini Alberto, Bellosta Stefano. Biology, 2021 vol. 10 no. 8
Uncovering the oral dysbiotic microbiota as masters of neutrophil responses in the pathobiology of periodontitis. Prucsi Zsombor, Płonczyńska Alicja, Potempa Jan, Sochalska Maja. Frontiers in Microbiology, 2021 vol. 12
Tuning the surface properties of poly(allylamine hydrochloride)-based multilayer films. Ciejka Justyna, Grzybala Michał, Gut Arkadiusz, Szuwarzyński Michał, Pyrć Krzysztof, Nowakowska Maria, Szczubiałka Krzysztof. Materials, 2021 vol. 14 no. 9
Structural determinants of substrate specificity of SplF protease from Staphylococcus aureus. Stach Natalia, Karim Abdulkarim, Golik Przemysław, Kitel Radosław, Pustelny Katarzyna, Gruba Natalia, Groborz Katarzyna, Jankowska Urszula, Kędracka-Krok Sylwia, Władyka Benedykt, Drag Marcin, Lesner Adam, Dubin Grzegorz. International Journal of Molecular Sciences, 2021 vol. 22 no. 4
hTERT-immortalized gingival fibroblasts respond to cytokines but fail to mimic primary cell responses to Porphyromonas gingivalis. Łagosz-Ćwik Katarzyna, Wielento Aleksandra, Lipska Weronika, Kantorowicz Małgorzata, Darczuk Dagmara, Kaczmarzyk Tomasz, Gibbs Susan, Potempa Jan , Grabiec Aleksander. Scientific Reports, 2021 vol. 11 no. 1
Subversion of lipopolysaccharide signaling in gingival keratinocytes via MCPIP-1 degradation as a novel pathogenic strategy of inflammophilic pathobionts. Gąsiorek Anna, Dobosz Ewelina, Potempa Barbara, Ciastoń Izabela, Wilamowski Mateusz, Oruba Zuzanna, Lamont Richard J., Jura Jolanta, Potempa Jan, Kozieł Joanna. MBio, 2021 vol. 12 no. 3
Porphyromonas gingivalis outer membrane vesicles as the major driver of and explanation for neuropathogenesis, the cholinergic hypothesis, iron dyshomeostasis, and salivary lactoferrin in Alzheimer’s disease. Nara Peter L., Sindelar Daniel, Penn Marc S., Potempa Jan , Griffin W. Sue T. Journal of Alzheimer's Disease, 2021 vol. 82 no. 4, p. 1417-1450
Intracellular Staphylococcus aureus employs the cysteine protease staphopain A to induce host cell death in epithelial cells. Stelzner Kathrin, Boyny Aziza, Hertlein Tobias, Sroka Aneta, Moldovan Adriana, Paprotka Kerstin, Kessie David, Mehling Helene, Potempa Jan, Ohlsen Knut, Fraunholz Martin J., Rudel Thomas. PLOS Pathogens, 2021 vol. 17 no. 9
The evaluation of microbiological colonization of cows' mammary glands before and after herbal treatment of mastitis. Kosecka-Strojek Maja, Lisowska-Łysiak Klaudia, Białecka Joanna, Białecka Anna, Kasprowicz Andrzej, Dudko Przemysław, Wójcik Piotr, Walczak Jacek, Międzobrodzki Jacek. Animal Science Papers and Reports, 2021 vol. 39 no. 4, p. 351-365
Distribution and antibiotic-resistance of different Staphylococcus species identified by matrix assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) isolated from the oral cavity. Garbacz Katarzyna, Wierzbowska Maria, Kwapisz Ewa, Kosecka-Strojek Maja , Bronk Marek, Saki Morteza, Międzobrodzki Jacek. Journal of Oral Microbiology, 2021 vol. 13 no. 1
Epidemiology and pathogenesis of Staphylococcus bloodstream infections in humans: a review. Lisowska-Łysiak Klaudia, Lauterbach Ryszard, Międzobrodzki Jacek, Kosecka-Strojek Maja. Polish Journal of Microbiology, 2021 vol. 70 no. 1, p. 13-23
C3-targeted therapy in periodontal disease: moving closer to the clinic. Hajishengallis George, Hasturk Hatice, Lambris John D., Apatzidou Danae A., Belibasakis Georgios N., Bostanci Nagihan, Corby Patricia M., Cutler Christopher W., D’Aiuto Francesco, Hajishengallis Evlambia, Huber-Lang Markus, Ioannidou Effie, Kajikawa Tetsuhiro, Kantarci Alpdogan, Korostoff Jonathan M., Kotsakis Georgios A., Maekawa Tomoki, Mastellos Dimitrios C., Moutsopoulos Niki M., Myneni Srinivas, Nagelberg Richard, Nilsson Bo, Papapanou Panos N., Papathanasiou Evangelos, Potempa Jan , Risitano Antonio, Sahingur S. Esra, Saito Atsushi, Sculean Anton, Stavropoulos Andreas, Teles Flavia R., Tonetti Maurizio, Yancopoulou Despina. Trends in Immunology, 2021 vol. 42 no. 10, p. 856-864
Ocena występowania genetycznych determinant warunkujących wielolekooporność wśród szczepów z gatunku Acinetobacter baumannii. Wawrzyniak Magdalena, Czekajewska Joanna, Kosecka-Strojek Maja, Nowak Paweł. Medycyna Doświadczalna i Mikrobiologia, 2021 t. 73 nr 1-4, s. 15-23
Occurrence of a single-species cyanobacterial bloom in a lake in Cyprus: monitoring and treatment with hydrogen peroxide-releasing granules. Keliri Eleni, Paraskeva Christia, Sofokleous Angelos, Sukenik Assaf, Dziga Dariusz, Chernova Ekaterina, Brient Luc, Antoniou Maria G. Environmental Sciences Europe, 2021 vol. 33
Phosphorylation of major Porphyromonas gingivalis virulence factors is crucial for their processing and secretion. Nowakowska Zuzanna, Madej Mariusz, Grad Sylwia, Wang Tiansong, Hackett Murray, Miller Daniel P., Lamont Richard J., Potempa Jan. Molecular Oral Microbiology, 2021 vol. 36 no. 6, p. 316-326
PorZ, an essential component of the type IX secretion system of Porphyromonas gingivalis, delivers anionic lipopolysaccharide to the PorU sortase for transpeptidase processing of T9SS cargo proteins. Madej Mariusz, Nowakowska Zuzanna, Książek Mirosław, Lasica Anna M., Mizgalska Danuta, Nowak Magdalena, Jacuła Anna, Bzowska Monika, Scavenius Carsten, Enghild Jan J., Aduse-Opoku Joseph, Curtis Michael A., Gomis-Ruth F. Xavier, Potempa Jan. MBio, 2021 vol. 12 no. 1
First case of Staphylococci carrying linezolid resistance genes from laryngological infections in Poland. Michalik Michał, Kosecka-Strojek Maja, Wolska Mariola, Samet Alfred, Podbielska-Kubera Adrianna, Międzobrodzki Jacek. Pathogens, 2021 vol. 10 no. 3
Intermolecular latency regulates the essential C-terminal signal peptidase and sortase of the Porphyromonas gingivalis type-IX secretion system. Mizgalska Danuta, Goulas Theodoros, Rodríguez-Banqueri Arturo, Veillard Florian, Madej Mariusz, Małecka Ewelina, Szczęśniak Katarzyna, Książek Mirosław, Widziołek-Pooranachandran Magdalena, Guevara Tibisay, Eckhard Ulrich, Solà Maria, Potempa Jan, Gomis-Rüth F. Xavier. Proceedings of the National Academy of Sciences of the United States of America, 2021 vol. 118 no. 40
The effect of major terpenes of the hop essential oil on the mixed monolayers and bilayers imitating bacteria membranes : in search of the natural pesticides. Połeć Karolina, Olechowska Karolina, Masłowiec Dominika, Wójcik Kinga, Hąc-Wydro Katarzyna. Journal of Molecular Liquids, 2021 vol. 327
In search of spectroscopic signatures of periodontitis : a SERS-based magnetomicrofluidic sensor for detection of Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans. Witkowska Evelin, Łasica Anna M., Niciński Krzysztof, Potempa Jan, Kamińska Agnieszka. ACS Sensors, 2021 vol. 6 no. 4, p. 1621-1635
The RagA and RagB proteins of Porphyromonas gingivalis. Potempa Jan, Madej Mariusz, Scott David A. Molecular Oral Microbiology, 2021 vol. 36 no. 4, p. 225-232
Mammalian-like type II glutaminyl cyclases in Porphyromonas gingivalis and other oral pathogenic bacteria as targets for treatment of periodontitis. Taudte Nadine, Linnert Miriam, Rahfeld Jens-Ulrich, Piechotta Anke, Daniel Ramsbeck, Buchholz Mirko, Kolenko Petr, Parthier Christoph, Houston John A., Veillard Florian , Eick Sigrun, Potempa Jan , Schilling Stephan, Demuth Hans-Ulrich, Stubbs Milton T. The Journal of Biological Chemistry, 2021 vol. 296
Small but potent: GTPases as novel players on the neutrophils autophagy market. Kozieł Joanna, Lech Maciej. Journal of Leukocyte Biology, 2021 vol. 110 no. 4, p. 613-615
Human skin microbiota-friendly lysostaphin. Bonar Emilia, Bukowski Michał, Chlebicka Kinga, Mądry Anna, Bereźnicka Anna, Kosecka-Strojek Maja, Dubin Grzegorz, Międzobrodzki Jacek, Mak Paweł, Władyka Benedykt. International Journal of Biological Macromolecules, 2021 vol. 183, p. 852-860
SARS‑CoV‑2 inhibition using a mucoadhesive, amphiphilic chitosan that may serve as an anti‑viral nasal spray. Pyrć Krzysztof, Milewska Aleksandra, Barreto Duran Emilia, Botwina Paweł, Dąbrowska Agnieszka, Jędrysik Malwina, Benedyk Małgorzata, Lopes Rui, Arenas‑Pinto Alejandro, Badr Moutaz, Mellor Ryan, Kalber Tammy L., Fernandez‑Reyes Delmiro, Schätzlein Andreas G., Uchegbu Ijeoma F. Scientific Reports, 2021 vol. 11
Serum complement activation by C4BP-IgM fusion protein can restore susceptibility to antibiotics in Neisseria gonorrhoeae. Bettoni Serena, Maziarz Karolina, Stone M. Rhia L., Blaskovich Mark A. T., Potempa Jan, Bazzo Maria Luiza, Unemo Magnus, Ram Sanjay, Blom Anna M. Frontiers in Immunology, 2021 vol. 12
Mouse IgG3 binding to macrophage-like cells is prevented by deglycosylation of the antibody or by Accutase treatment of the cells. Hinz Alicja, Bzowska Monika, Bereta Joanna, Czarnek Maria, Sochalska Maja, Klaus Tomasz. Scientific Reports, 2021 vol. 11
Staphylococcus aureus uses the ArlRS and MgrA cascade to regulate immune evasion during skin infection. Kwieciński Jakub, Kratofil Rachel M., Parlet Corey P., Surewaard Bas G. J., Kubes Paul, Horswill Alexander R. Cell Reports, 2021 vol. 36 no. 4
Lipidation of temporin-1CEb derivatives as a tool for activity improvement, pros and cons of the approach. Kosikowska-Adamus Paulina, Sikorska Emilia, Wyrzykowski Dariusz, Walewska Aleksandra, Golda Anna , Deptula Milena, Obuchowski Michał, Prahl Adam, Pikuła Michał, Lesner Adam. International Journal of Molecular Sciences, 2021 vol. 22 no. 13
AXL targeting by a specific small molecule or monoclonal antibody inhibits renal cell carcinoma progression in an orthotopic mice model. Chen Tony J., Mydel Piotr, Benedyk-Machaczka Małgorzata, Kamińska Marta , Kalucka Urszula, Blø Magnus, Furriol Jessica, Gausdal Gro, Lorens James, Osman Tarig, Marti Hans-Peter. Physiological Reports, 2021 vol. 9 no. 23
Effect of Staphylococcus aureus infection on the heat stress protein 70 (HSP70) level in chicken embryo tissues. Kosecka-Strojek Maja, Trzeciak Jakub, Homa Joanna, Trzeciak Karolina, Władyka Benedykt, Trela Magdalena, Międzobrodzki Jacek , Lis Marcin W. Poultry Science, 2021 vol. 100 no. 6
Deletion of Mcpip1 in mice recapitulates the phenotype of human primary biliary cholangitis. Kotlinowski Jerzy, Hutsch Tomasz, Czyżyńska-Cichoń Izabela, Wadowska Marta, Pydyn Natalia, Jasztal Agnieszka, Kij Agnieszka, Dobosz Ewelina, Lech Maciej, Miękus Katarzyna, Pośpiech Ewelina, Fu Mingui, Jura Jolanta, Kozieł Joanna, Chłopicki Stefan. Biochimica et Biophysica Acta. Molecular Basis of Disease, 2021 vol. 1867 no. 5
Mechanisms of vascular damage by systemic dissemination of the oral pathogen Porphyromonas gingivalis. Farrugia Cher, Stafford Graham P., Potempa Jan, Wilkinson Robert N., Chen Yan, Murdoch Craig, Widziołek-Pooranachandran Magdalena. The FEBS Journal, 2021 vol. 288 no. 5, p. 1479-1495
HTCC as a polymeric inhibitor of SARS-CoV-2 and MERS-CoV. Milewska Aleksandra, Chi Ying, Szczepański Artur, Barreto Duran Emilia, Dąbrowska Agnieszka, Botwina Paweł, Obłoza Magdalena, Liu Kevin, Liu Dan, Guo Xiling, Ge Yiyue, Li Jingxin, Cui Lunbiao, Ochman Marek, Urlik Maciej, Rodziewicz-Motowidlo Sylwia, Zhu Fengcai, Szczubiałka Krzysztof, Nowakowska Maria, Pyrć Krzysztof. Journal of Virology, 2021 vol. 95 no. 4
Latency, thermal stability, and identification of an inhibitory compound of mirolysin, a secretory protease of the human periodontopathogen Tannerella forsythia. Zak Krzysztof M., Bostock Mark J., Waligórska Irena, Thøgersene Ida. B., Enghild Jan J., Popowicz Grzegorz M., Grudnik Przemysław, Potempa Jan, Książek Mirosław. Journal of Enzyme Inhibition and Medicinal Chemistry, 2021 vol. 36 no. 1, p. 1267-1281
Antimicrobial photodynamic therapy effectively reduces Porphyromonas gingivalis infection in gingival fibroblasts and keratinocytes: an in vitro study. Oruba Zuzanna, Gawron Katarzyna, Bereta Grzegorz, Sroka Aneta, Potempa Jan, Chomyszyn-Gajewska Maria. Photodiagnosis and Photodynamic Therapy, 2021 vol. 34
Role of Mcpip1 in obesity-induced hepatic steatosis as determined by myeloid and liver-specific conditional knockouts. Pydyn Natalia, Żurawek Dariusz, Kozieł Joanna, Kuś Edyta, Wojnar-Lasoń Kamila , Jasztal Agnieszka , Fu Mingui, Jura Jolanta , Kotlinowski Jerzy. The FEBS Journal, 2021 vol. 288 no. 22, p. 6563-6580
Bioactive yet antimicrobial structurally stable collagen/chitosan/lysine functionalized hyaluronic acid : based injectable hydrogels for potential bone tissue engineering applications. Gilarska Adriana , Lewandowska-Łańcucka Joanna, Guzdek-Zając Katarzyna, Karewicz Anna, Horak Wojciech, Lach Radosław, Wójcik Kinga, Nowakowska Maria. International Journal of Biological Macromolecules, 2020 vol. 155, p. 938-950
Proteolysis of gingival keratinocyte cell surface proteins by gingipains secreted from Porphyromonas gingivalis: proteomic insights into mechanisms behind tissue damage in the diseased gingiva. Hočevar Katarina, Vizovišek Matej, Wong Alicia, Kozieł Joanna, Fonović Marko, Potempa Barbara, Lamont Richard J., Potempa Jan, Turk Boris. Frontiers in Microbiology, 2020 vol. 11
Structure-based mechanism of cysteine-switch latency and of catalysis by pappalysin-family metallopeptidases. Guevara Tibisay, Rodriguez-Banqueri Arturo, Książek Mirosław, Potempa Jan, Gomis-Rüth F. Xavier. IUCrJ, 2020 vol. 7 no. 1, p. 18-29
Water envelope has a critical impact on thedesign of protein-protein interaction inhibitors. Ratkova Ekaterina L., Dawidowski Maciej, Napolitano Valeria, Dubin Grzegorz, Fino Roberto, Ostertag Michael S., Satter Michael, Popowicz Grzegorz, Tetko Igor V. Chemical Communications, 2020 vol. 56 no. 31, p. 4360-4363
Treatment of severe periodontitis may improve clinical disease activity in otherwise treatment-refractory rheumatoid arthritis patients. Möller Burkhard, Bender Philip, Eick Sigrun, Kuchen Stefan, Maldonado Alejandra, Potempa Jan, Reichenbach Stephan, Sculean Anton, Schwenzer Anja, Villiger Peter M., Wong Alicia, Midwood Kim S. Rheumatology, 2020 vol. 59 no. 1, p. 243-245
Porphyromonas gingivalis genes conferring fitness in a tobacco-rich environment. Hutcherson Justin A., Gogenini Himabindu, Lamont Gwyneth J., Miller Daniel P., Nowakowska Zuzanna, Lasica Anna M., Liu Chengcheng, Potempa Jan, Lamont Richard J., Yoder-Himes Deborah, Scott David A. Molecular Oral Microbiology, 2020 vol. 35 no. 1, p. 10-18
Peptidylarginine deiminase 4 (PAD4) activity in early rheumatoid arthritis. Jonsson M. K., Kantyka Tomasz, Falkowski Katherine, Aliko A., Aga A. B., Lillegraven S., Sexton J., Fevang B. T., Mydel Piotr, Haavardsholm E. A. Scandinavian Journal of Rheumatology, 2020 vol. 49 no. 2, p. 87-95
Peptidylarginine deiminase of Porphyromonas gingivalis modulates the interactions between Candida albicans biofilm and human plasminogen and high-molecular-mass kininogen. Karkowska-Kuleta Justyna, Surowiec Magdalena, Gogól Mariusz, Kozieł Joanna, Potempa Barbara, Potempa Jan, Kozik Andrzej, Rąpała-Kozik Maria. International Journal of Molecular Sciences, 2020 vol. 21 no. 7
Structure-activity relationship in pyrazolo 4,3-c pyridines, first inhibitors of PEX14-PEX5 protein-protein interaction with trypanocidal activity. Dawidowski Maciej, Kalel Vishal C., Napolitano Valeria, Fino Robert, Schorpp Kenji, Emmanouilidis Leonidas, Lenhart Dominik, Ostertag Michael, Kaiser Marcel, Kolonko Marta, Tippler Bettina, Schliebs Wolfgang, Dubin Grzegorz, Mäser Pascal, Tetko Igor V., Hadian Kamyar, Plettenburg Oliver, Erdmann Ralf, Sattler Michael, Popowicz Grzegorz M. Journal of Medicinal Chemistry, 2020 vol. 63 no. 2, p. 847-879
Preliminary evaluation of application of a 3-dimensional network structure of siloxanes Dergall preparation on chick embryo development and microbiological status of eggshells. Patrzałek Michał, Kosecka-Strojek Maja, Lisowska-Łysiak Klaudia, Trela Magdalena, Kot Mariusz, Gawlak Magdalena, Liszka Dawid, Sajewicz Mieczysław, Tombarkiewicz Barbara, Pawlak Krzysztof, Międzobrodzki Jacek, Lis Marcin W. Poultry Science, 2020 vol. 99 no. 3, p. 1581-1590
Targeting histone deacetylases for bacterial infections. Łagosz-Ćwik Katarzyna, Grabiec Aleksander. Histone modifications in therapy, 2020. - p. 237-254
Emergence of linezolid-resistant Staphylococcus epidermidis in the tertiary children's hospital in Cracow, Poland. Kosecka-Strojek Maja, Sadowy Ewa, Gawryszewska Iwona, Klepacka Joanna, Tomasik Tomasz, Michalik Michał, Hryniewicz Waleria, Międzobrodzki Jacek. European Journal of Clinical Microbiology & Infectious Diseases, 2020 vol. 39 no. 9, p. 1717-1725
Apolipoprotein E triggers complement activation in joint synovial fluid of rheumatoid arthritis patients by binding C1q. Vogt Leonie M., Kwasniewicz Ewa, Talens Simone, Scavenius Carsten, Bielecka Ewa, Ekdahl Kristina N., Enghild Jan J., Mörgelin Matthias, Saxne Tore, Potempa Jan, Blom Anna M. The Journal of Immunology, 2020 vol. 204 no. 10, p. 2779-2790
Candida albicans shields the periodontal killer Porphyromonas gingivalis from recognition by the host immune system and supports the bacterial infection of gingival tissue. Bartnicka Dominika, Gonzalez Gonzalez Miriam, Sykut Joanna, Kozieł Joanna, Ciastoń Izabela, Adamowicz Karina, Braś Grażyna, Zawrotniak Marcin, Karkowska-Kuleta Justyna, Satała Dorota, Kozik Andrzej, Żyła Edyta, Gawron Katarzyna, Łazarz-Bartyzel Katarzyna, Chomyszyn-Gajewska Maria , Rąpała-Kozik Maria. International Journal of Molecular Sciences, 2020 vol. 21 no. 6
Coagulase-negative staphylococci (CoNS) as a significant etiological factor of laryngological infections: a review. Michalik Michał, Samet Alfred, Podbielska-Kubera Adrianna, Savini Vincenzo, Międzobrodzki Jacek, Kosecka-Strojek Maja. Annals of Clinical Microbiology and Antimicrobials, 2020 vol. 19
Ancestrally duplicated conserved noncoding element suggests dual regulatory roles of HOTAIR in cis and trans. Nepal Chirag, Taranta Andrzej, Hadzhiev Yavor, Pundhir Sachin, Mydel Piotr, Lenhard Boris, Müller Ferenc, Andersen Jesper B. iScience, 2020 vol. 23 no. 4
Application of the in vitro HoxB8 model system to characterize the contributions of neutrophil-LPS interaction to periodontal disease. Sochalska Maja, Stańczyk Magdalena B., Użarowska Maria, Zubrzycka Natalia, Kirschnek Susanne, Grabiec Aleksander, Kantyka Tomasz, Potempa Jan. Pathogens, 2020 vol. 9 no. 7
Kallikrein-related peptidase 14 activates zymogens of membrane type matrix metalloproteinases (MT-MMPs) : a CleavEx based analysis. Falkowski Katherine, Bielecka Ewa, Thøgersen Ida B., Bocheńska Oliwia, Płaza Karolina , Kalińska Magdalena, Sąsiadek Laura, Magoch Małgorzata, Pęcak Aleksandra , Wiśniewska Magdalena , Gruba Natalia, Wysocka Magdalena, Wojtysiak Anna, Brzezińska-Bodal Magdalena, Sychowska Kamila, Pejkovska Anastasija, Rehders Maren, Butler Georgina, Overall Christopher M., Brix Klaudia, Dubin Grzegorz, Lesner Adam, Kozik Andrzej, Enghild Jan J., Potempa Jan, Kantyka Tomasz. International Journal of Molecular Sciences, 2020 vol. 21 no. 12
Analysis of oral microbiome from fossil human remains revealed the significant differences in virulence factors of modern and ancient Tannerella forsythia. Philips Anna, Stolarek Ireneusz, Handschuh Luiza, Nowis Katarzyna, Juras Anna, Trzciński Dawid, Nowaczewska Wioletta, Wrzesińska Anna, Potempa Jan, Figlerowicz Marek. BMC Genomics, 2020 vol. 21
Chronic exposure of gingival fibroblasts to TLR2 or TLR4 agonist inhibits osteoclastogenesis but does not affect osteogenesis. Karlis Gerasimos D., Schoningh Emily, Jansen Ineke D. C., Schoenmaker Ton, Hogervorst Jolanda M. A., van Veen Henk A., Moonen Carolyn G. J., Łagosz-Ćwik Katarzyna, Forouzanfar Tim, de Vries Teun J. Frontiers in Immunology, 2020 vol. 11
Synoviocyte-targeted therapy synergizes with TNF inhibition in arthritis reversal. Svensson Mattias N. D., Zoccheddu Martina, Yang Shen, Nygaard Gyrid, Secchi Christian, Doody Karen M., Slowikowski Kamil, Mizoguchi Fumitaka, Humby Frances, Hands Rebecca, SanteIli Eugenio, Sacchetti Cristiano, Wakabayashi Kuninobu, Wu Dennis J., Barback Christopher, Ai Rizi, Wang Wei, Sims Gary P., Mydel Piotr, Kasama Tsuyoshi, Boyle David L., Galimi Francesco, Vera David, Tremblay Michel L., Raychaudhuri Soumya, Brenner Michael B., Firestein Gary S., Pitzalis Costantino, Ekwall Anna-Karin H., Stanford Stephanie M., Bottini Nunzio. Science Advances, 2020 vol. 6 no. 26
Presence of egc-positive major clones ST 45, 30 and 22 among methicillin-resistant and methicillin-susceptible oral Staphylococcus aureus strains. Kwapisz Ewa, Garbacz Katarzyna, Kosecka-Strojek Maja, Schubert Justyna, Bania Jacek, Międzobrodzki Jacek. Scientific Reports, 2020 vol. 10
Identification of cinically relevant Streptococcus and Enterococcus species based on biochemical methods and 16S rRNA, sodA, tuf, rpoB, and recA gene sequencing. Kosecka-Strojek Maja, Wolska Mariola, Żabicka Dorota, Sadowy Ewa, Międzobrodzki Jacek. Pathogens, 2020 vol. 9 no. 11
Kallikrein 13 serves as a priming protease during infection by the human coronavirus HKU1. Milewska Aleksandra, Falkowski Katherine, Kulczycka Magdalena, Bielecka Ewa, Naskalska Antonina, Mak Paweł, Lesner Adam, Ochman Marek, Urlik Maciej, Diamandis Elftherios, Prassas Ioannis, Potempa Jan, Kantyka Tomasz, Pyrć Krzysztof. Science Signaling, 2020 vol. 13 no. 659
Epigenetic regulation of inflammation in periodontitis: cellular mechanisms and therapeutic potential. Jurdziński Krzysztof T., Potempa Jan, Grabiec Aleksander. Clinical Epigenetics, 2020 vol. 12
Neurturin regulates the lung-resident macrophage inflammatory response to viral infection. Connolly Emma, Morgan David J., Franklin Miriam, Simpson Angela, Shah Rajesh, Brand Oliver J., Jagger Christopher P., Casulli Joshua, Mohamed Karishma, Grabiec Aleksander, Hussell Tracy. Life Science Alliance, 2020 vol. 3 no. 12
Citrullination-resistant LL-37 is a potent antimicrobial agent in the inflammatory environment high in arginine deiminase activity. Bryzek Danuta, Golda Anna, Budziaszek Joanna, Kowalczyk Dominik, Wong Alicia, Bielecka Ewa, Shakamuri Priyanka, Svoboda Pavel, Pohl Jan, Potempa Jan, Kozieł Joanna. InternationalJournal of Molecular Sciences, 2020 vol. 21 no. 23
Different gene expression response of Polish and Australian Raphidiopsis raciborskii strains to the chill/light stress. Antosiak Adam, Tokodi Nada, Maziarz Robert, Kokociński Mikołaj, Brzozowska Agnieszka, Strzałka Wojciech, Banaś Agnieszka, Willis Anusuya, Dziga Dariusz. Applied Sciences, 2020 vol. 10 no. 16
Phenolic-enriched collagen fibrillar coatings on titanium alloy to promote osteogenic differentiation and reduce inflammation. Mieszkowska Anna, Beaumont Harrison, Martocq Laurine, Koptyug Andrey, Surmeneva Maria A., Surmenev Roman A., Naderi Javad, Douglas Timothy E. L., Gurzawska-Comis Katarzyna A. International Journal of Molecular Sciences, 2020 vol. 21 no. 17
The dark side of UV-induced DNA lesion repair. Strzałka Wojciech, Zgłobicki Piotr, Kowalska Ewa, Bażant Aneta, Dziga Dariusz, Banaś Agnieszka. Genes, 2020 vol. 11 no. 12
Structural and functional insights into oligopeptide acquisition by the RagAB transporter from Porphyromonas gingivalis. Madej Mariusz, White Joshua B. R., Nowakowska Zuzanna, Rawson Shaun, Scavenius Carsten, Enghild Jan J., Bereta Grzegorz, Pothula Karunakar, Kleinekathoefer Ulrich, Baslé Arnaud, Ranson Neil A., Potempa Jan, van den Berg Bert. Nature Microbiology, 2020 vol. 5 no. 8, p. 1016-1025
Citrullinome of Porphyromonas gingivalis outer membrane vesicles: confident identification of citrullinated peptides. Larsen Daniel Nyberg, Mikkelsen Christian Engelbrecht, Kierkegaard Mads, Bereta Grzegorz, Nowakowska Zuzanna, Kaczmarek Jakub Z., Potempa Jan , Højrup Peter. Molecular & Cellular Proteomics, 2020 vol. 19 no. 1, p. 167-180
The SARS-CoV-2 ORF10 is not essential in vitro or in vivo in humans. Pancer Katarzyna, Milewska Aleksandra, Owczarek Katarzyna, Dąbrowska Agnieszka, Kowalski Michał, Łabaj Paweł, Branicki Wojciech, Sanak Marek, Pyrć Krzysztof. PLOS Pathogens, 2020 vol. 16 no. 12
Visualization of SARS-CoV-2 using immuno RNA-fluorescence in situ hybridization. Kula-Păcurar Anna, Wadas Jakub, Suder Agnieszka, Szczepański Artur, Milewska Aleksandra, Ochman Marek, Stacel Tomasz, Pyrć Krzysztof. Journal of Visualized Experiments, 2020 vol. 166
Replication of severe acute respiratory syndrome coronavirus 2 in human respiratory epithelium. Milewska Aleksandra, Kula-Păcurar Anna, Wadas Jakub, Suder Agnieszka, Szczepański Artur, Dąbrowska Agnieszka, Owczarek Katarzyna, Marcello Alessandro, Ochman Marek, Stacel Tomasz, Rajfur Zenon, Sanak Marek, Łabaj Paweł, Branicki Wojciech, Pyrć Krzysztof. Journal of Virology, 2020 vol. 94 no. 15
Plasmin inhibition by bacterial serpin : implications in gum disease. Sochaj-Gregorczyk Alicja, Książek Mirosław, Waligórska Irena, Straczek Anna, Benedyk-Machaczka Małgorzata, Mizgalska Danuta, Thøgersen Ida B., Enghild Jan J., Potempa Jan. The FASEB Journal, 2020 vol. 34 no. 1, p. 619-630
All you need is light : photorepair of UV-induced pyrimidine dimers. Banaś Agnieszka, Zgłobicki Piotr, Kowalska Ewa, Bażant Aneta, Dziga Dariusz, Strzałka Wojciech. Genes, 2020 vol. 11 no. 11
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