Batchelor & Master thesis topics

• Identification of bacterial and virial virulence factors.
• The role of epigenetic mechanisms in pathogen-host interaction.
• Modulation of immunological response during infection.
• Potranslational protein modifications during inflammation.
• Discovery and characterization of novel bacterial proteolytic enzymes and their proteinaceous inhibitors Identification of protease inhibitors of potential therapeutic importance.
• The influence of apoptotic proteins on the function and survival of immune system cells in the development of periodontal inflammatory disease (in vitro, in vivo, ex vivo).
• Genetic and enzymatic bacterial strains typing.
• The role of MALT-1 paracaspase in periodontal diseases.
• Modulation of fibroblast function by oral pathogens.
• Structural and functional study of the proteins of the T9SS secretion system.
• Investigation of the unique signaling pathway responsible for P. gingivalis virulence.
• Study of the membrane system of peptide uptake by P. gingivalis, i.e. how P. gingivalis nourishes.
• Phenotypic and genetic plasticity in Staphylococcus strains from bloodstream infections and healthy individuals.
• Staphylococcus aureus vs. Staphylococcus lugdunensis – synergy or antagonism?
• Gram-positive bacteria biofilms.
• Role of microbiome in diseases.
• Antibiotic resistance pandemic – genetic analysis of multidrug resistant Staphylococcus aureus strains.
• Search for novel anti-infective therapies.
• Competition  for TLR2 binding between S.gordonii peptidoglican and P.gingivalis fimbriae.