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Research topics

  • Pathogenesis of autoimmune diseases, including rheumatoid arthritis
  • Role of negative inflammatory regulators in bacterial infection
  • Role of kallikrein-related proteases in EGF-related signal transduction
  • Role of arginine citrullination in the protease-inhibitor interactions in the context of innate immunity system
  • Significance of bacterial citrullination of host proteins/peptides in pathogenesis of periodontal disease
  • Role of citrullination in healing and regeneration of periodontal tissues
  • Petiopathogenesis and novel approaches to therapy of gingival fibromatosis
  • Defense mechanisms of bacteria
  • Epigenetics of bacterial infections
  • Apoptosis of immune cells and its role in the development of periodontitis 
  • Molecular mechanisms of bacterial opportunistic infections
  • Genetic and phenotypic typing of clinically significant bacterial pathogens
  • Pathogens transmission between human and animal
  • Next generation sequencing (NGS) in medical microbiology
  • The role of fibroblast in the pathogenesis of periodontitis
  • Significance of citrullination catalyzed by PPAD in the pathogenesis of periodontitis
  • Impact of citrullination on periodontal tissues healing and regeneration
  • Significance of the polymorphisms in the PPAD gene from P. gingivalis in the pathogenesis and prognosis of periodontal disease
  • Molecular mechanisms and novel attempts to therapy of gingival fibromatosis
  • Proteases and their protein inhibitors
  • Mechanisms underlying clinical and epidemiological connections between periodontitis (parodontosis) and bacteria responsible for the development of periodontosis and systemic human diseases
  • Metagenomics and transcriptomics (RNASeq) in bacterial infections molecular diagnostics
  • Platelets in the Uremic Milieu – The link between protein carbamylation and platelet dysfunctions in end stage renal disease
  • Molecular basis of the nutrition of asacharolytic bacteria
  • Structural biology of P. gingivalis membrane complexes
  • Search for new secretion systems of virulence factors
  • Study of unique gene expression regulation systems
  • Etiology and pathogenesis of neutropenia
  • Molecular mechanisms of staphylococcal infections
  • Role of glycosaminoglycans as modulators of immune responses
  • Novel anti-infective therapies